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A recent study has found that repetitive Transcranial Magnetic Stimulation (rTMS) is effective in treating depression. The results showed that the majority of patients experienced a significant reduction in symptoms, with some even achieving complete remission.

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The combination of TMS (Transcranial Magnetic Stimulation) treatments and Ketamine Infusions is gaining national attention as a powerful way to alleviate Treatment Resistant Depression. For more information or to schedule an assessment call or text us at 330-754-4844.

Spravato for Mental Health

Everything You Need to Know

Mental health treatment is undergoing a revolution with the introduction of Spravato. This breakthrough therapy offers new hope for individuals suffering from treatment-resistant depression and acute suicidality. Spravato, also known as ketamine, transforms lives by providing rapid relief from symptoms where traditional treatments have failed. Discover how Spravato is changing the mental health landscape and offering a lifeline to those in need.

What is Spravato?

Spravato, known scientifically as esketamine, is a cutting-edge medication approved by the FDA specifically for treatment-resistant depression. Unlike conventional antidepressants that can take weeks or even months to show effects, Spravato offers a more immediate response, which is crucial for patients who have not found relief through standard treatments. Administered as a nasal spray, Spravato provides a new avenue for relief by delivering medication directly into the bloodstream via the nasal passages.

Traditional antidepressants generally target neurotransmitters like serotonin, norepinephrine, and dopamine. These medications typically work by altering the levels of these chemicals in the brain to improve mood and alleviate symptoms of depression. However, this approach does not work for everyone. For those who have not responded to at least two different antidepressant treatments, Spravato represents a promising alternative.

How Does Spravato Work?

Spravato’s mechanism of action is fundamentally different from that of traditional antidepressants. It targets the N-methyl-D-aspartate (NMDA) receptors in the brain. These receptors are part of the glutamate system, the most abundant excitatory neurotransmitter system in the brain, and crucial for synaptic plasticity, a process vital for learning and memory.

By modulating the activity of the NMDA receptors, Spravato influences the levels of glutamate. This modulation leads to a cascade of events in the brain that can result in the rapid alleviation of depressive symptoms. The exact pathways are complex but involve synaptic connections and brain plasticity changes, which can quickly improve mood and cognitive functions.

One of the standout features of Spravato is its rapid onset of action. Patients often begin to notice an improvement in their symptoms within hours or days, as opposed to the weeks required for traditional antidepressants. This quick response is especially important for individuals with severe depression or those experiencing suicidal thoughts, as it provides a much-needed sense of hope and relief.

Moreover, Spravato is used in conjunction with an oral antidepressant, creating a comprehensive treatment plan. This combination ensures that patients receive both immediate and long-term benefits. The treatment regimen typically starts with twice-weekly doses during the initial phase, gradually tapering to weekly or bi-weekly maintenance doses based on the patient’s response and needs.

In summary, Spravato offers a novel approach to treating depression by targeting NMDA receptors and modulating glutamate levels. Its rapid action and efficacy in treatment-resistant cases make it a vital tool in the arsenal against severe depression, providing new hope for patients who have struggled with other treatments.

Uses of Spravato in Mental Health Treatment 

Treating Treatment-Resistant Depression

Treatment-resistant depression affects individuals who do not respond to standard treatments. Spravato has shown significant efficacy in alleviating symptoms in such cases, offering hope where other treatments have failed.

Addressing Acute Suicidality

Spravato is particularly effective for individuals experiencing acute suicidality. Its rapid onset of action can stabilize patients quickly, reducing the immediate risk and allowing for further therapeutic interventions.

Benefits of Spravato

  • Rapid Onset: Effects can be felt within hours.
  • Long-Term Benefits: When combined with therapy, Spravato provides lasting relief.
  • Holistic Approach: At Ascend Health Center, Spravato is part of a comprehensive treatment plan.

Treatment Process with Spravato

Initial Consultation and Assessment

At Ascend Health Center, the journey with Spravato begins with a comprehensive initial consultation. Each patient undergoes a detailed evaluation to determine their suitability for Spravato treatment. This process involves a thorough medical and psychiatric assessment, including a review of the patient’s history, current symptoms, and previous treatments. The aim is to identify treatment-resistant depression or acute suicidality and ensure that Spravato is the appropriate intervention. This personalized approach allows the medical team to tailor the treatment plan to each individual’s specific needs, optimizing the chances of success.

Administration of Spravato

Spravato is administered intranasally under strict medical supervision at Ascend Health Center. The administration process is straightforward yet meticulously monitored to ensure patient safety and efficacy of the treatment. Here’s a step-by-step breakdown of what patients can expect:

  1. Preparation: Before administration, patients are briefed about the procedure and what to expect during and after the session. They are also advised to avoid eating for a few hours before the treatment to minimize potential nausea.
  2. Dosing: The nasal spray is self-administered under the guidance of a healthcare professional. Patients usually receive a starting dose, which may be adjusted in subsequent sessions based on their response and tolerability.
  3. Monitoring: After administration, patients must remain in a comfortable, supervised setting at the clinic for at least two hours. Healthcare professionals monitor vital signs, mental status, and any side effects during this time. This observation period is crucial to manage immediate reactions and ensure patient safety.
  4. Post-Treatment: Patients are assessed before they leave to ensure they are stable and not experiencing significant side effects. They are also advised not to drive or operate heavy machinery until the day after the treatment.

Integration with Other Therapies

While Spravato is a powerful treatment for depression, it is most effective when integrated with other therapeutic approaches. Ascend Health Center emphasizes a holistic and multidisciplinary approach to mental health care, combining Spravato with various psychotherapy and supportive therapies. This integration includes:

  1. Cognitive-Behavioral Therapy (CBT): This evidence-based therapy helps patients address negative thought patterns and behaviors that contribute to their depression. CBT is often used in conjunction with Spravato to provide a comprehensive treatment strategy.
  2. Mindfulness and Relaxation Techniques: These practices help patients manage stress and anxiety, enhancing the overall effectiveness of Spravato treatment.
  3. Support Groups and Counseling: Engaging in group therapy or individual counseling provides additional support and helps patients feel connected and understood during their treatment journey.
  4. Lifestyle and Wellness Programs: Ascend Health Center may also incorporate lifestyle modifications such as exercise, nutrition, and sleep hygiene into the treatment plan, promoting overall well-being and supporting mental health recovery.

By combining Spravato with these therapies, Ascend Health Center ensures that patients receive a well-rounded and effective treatment plan tailored to their unique needs.

Patient Experience 

Addressing Common Concerns

Side Effects: Spravato, like all medications, can cause side effects. The most common ones include dizziness and dissociation, which is a feeling of being disconnected from oneself or one’s surroundings. These side effects are usually transient and mild to moderate in severity. At Ascend Health Center, patients are closely monitored for two hours after administration to ensure their safety and comfort. Healthcare professionals are on hand to manage any side effects that arise. The center’s priority is to ensure that each patient’s experience is as comfortable and safe as possible.

Cost and Insurance: The cost of Spravato treatment can be a significant concern for many patients. Ascend Health Center understands this and works diligently to assist patients in navigating their insurance coverage and managing costs. The center collaborates with insurance providers to determine coverage eligibility and help minimize out-of-pocket expenses. Patients receive guidance on the prior authorization process, which insurance companies often require for Spravato treatment. Additionally, Ascend Health Center provides transparent information about the cost of treatment and any financial assistance programs that may be available. This proactive approach ensures that financial concerns do not hinder access to this potentially life-changing treatment.

Ascend Health Center: Your Partner in Spravato Use


Ascend Health Center is transforming the landscape of mental health treatment with the innovative use of Spravato. This breakthrough therapy offers a lifeline to those grappling with treatment-resistant depression and acute suicidality, conditions that can feel overwhelming and isolating. Spravato provides rapid relief by targeting the NMDA receptor in the brain, often producing noticeable improvements in symptoms within hours of administration.

If you or someone you know is struggling with treatment-resistant depression or acute suicidality, exploring the benefits of Spravato at Ascend Health Center could be a pivotal step toward recovery. Don’t let depression define your life—embrace the possibility of a brighter future with Spravato and the exceptional care provided by Ascend Health Center. Reach out today to learn more and take the first step on your journey to mental wellness.

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